Always check with your vet if your dog is taking any medication and you are seeing aggression, If your dog is already aggressive, check with your vet whether there is any chance that a side effect could make your dog’s behavior worse.

Some common medications that can contribute to aggression

Prednisone is a steroid used to reduce inflammation. It may be used to treat inflammation, Cancer, Addison’s Disease, and Nervous System Disorders.(1)

Phenobarbital (required medication for seizures), can cause aggression but may be also be prescribed for treating aggression related to seizures.

Corticosteroids are used for a number of different conditions that involve the inflammatory and immune systems such as arthritis, allergies, etc. They should not be stopped abruptly without talking to your vet, especially if your dog has been taking them regularly as it may cause dangerous side effects. If you think they are causing your dog to be aggressive, speak to your vet.

NSAIDs are also anti-inflammatory medications. They are often prescribed for treating pain.

Aggression is not listed as the most common side effects of these drugs, and can be prescribed to some dogs that are already aggressive without making their aggression worse, but it is a good idea to be aware that these medications can play a factor in aggression.

Rarely, some medications prescribed for aggression can have the opposite effect, so careful monitoring should be done to determine if the medication is helping or making things worse.

Keep in mind that any dog who is not feeling well may show aggression.  Read more on medical conditions that can contribute to aggression

See Medications used for treating dog aggression


(1) Prednisone Prednisolone, WebMD,